Radiosensitization of HRAS Mutated Head and Neck Cancer
نویسندگان
چکیده
منابع مشابه
Quality of life in head and neck cancer patients
Quality of life in head and neck cancer patients
متن کاملNQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer.
UNLABELLED Ionizing radiation (IR) is a key therapeutic regimen for many head and neck cancers (HNC). However, the 5-year overall survival rate for locally advanced HNCs is approximately 50% and better therapeutic efficacy is needed. NAD(P)H quinone oxidoreductase 1 (NQO1) is overexpressed in many cancers, and β-lapachone (β-lap), a unique NQO1 bioactivatable drug, exploits this enzyme to rel...
متن کاملHead and neck cancer.
Most head and neck cancers are squamous cell carcinomas that develop in the upper aerodigestive epithelium after exposure to carcinogens such as tobacco and alcohol. Human papillomavirus has also been strongly implicated as a causative agent in a subset of these cancers. The complex anatomy and vital physiological role of the tumour-involved structures dictate that the goals of treatment are no...
متن کاملHead and Neck Cancer
Head and neck cancer is traditionally thought of as being a disease associated with alcohol and tobacco abuse and deprivation. It was the fourth most common cancer in males in Scotland in 2000 and just over 1,000 cases were diagnosed in 2007. As smoking becomes less prevalent, a fall in the incidence of head and neck cancer could be anticipated; however, increasing evidence of other aetiologica...
متن کاملHead and neck cancer
More than 600,000 head and neck cancers (HNC) are diagnosed every year and the incidence and mortality rates vary according to the economical status of the country. Most are oral, pharyngeal or laryngeal squamous cell carcinomas. The most significant risk factors include lifestyle habits (tobacco, alcohol drinking and diet). More recently, exposure to some biological agents (HPV and EBV) and ge...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2017
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2017.06.2020